1. NIDDK LABS Center (DK 03-006)
- PI: Paul Berk
- LABS 2, Longitudinal Assessment of Bariatric Surgery (LABS 2 #0508008060)
- PI (Weill Cornell): Dr. Alfons Pomp
- Investigators: Dr. Gladys Strain, Dr. Gregory Dakin, Mrs. Faith Ebel and Ms. Michelle Capasso
Aims:
- As a follow-up to the LABS 1 study previously completed which examined the 30 day mortality rate after bariatric procedures in 1200 patients, the LABS 2 study is a comprehensive longer term assessment of 2,400 patients. This protocol will assess the long-term effects of weight loss on health, gender issues, behavioral factors, work issues and leisure activities over 3 years.
- For more information on the LABS Consortium and their ongoing research go to: www.niddklabs.org
2. Data Collection Project for Weight Loss Surgery (0502007736)
- PI: Dr. Pomp
- Investigators: Dr. Dakin, Dr. Strain, Capasso, and Ebel
Aims:
- All patients who receive weight loss surgery are asked for their permission to use their data on basic demographics, type of surgery and possible complications prior to and following surgery for comparative purposes
- Nothing is required of the patient other than permission to use their information
- The purpose of this study is to learn more about how weight loss occurs with surgery, possible complications of surgery and how the different surgeries compare
3. Body Composition and REE Responses to Bariatric Surgeries (NIH, DK 03-022 sub contract to Weill Cornell)
- PI: Dympna Gallagher, Ed.D
- PI: Dr. Strain, Weill Cornell (No Weill Cornell IRB approval required)
- Investigators: Drs. Pomp, Dakin
Aims:
- Consenting patients (52) will undergo multiple studies prior to and following bariatric procedures of body composition in order to examine the changes that occur. Measurement include total intracellular and extracellular body water, skeletal muscle mass, organ sizes, and bone mineral content using dilution techniques, MRI, and dual energy-X-ray absorptiometry
- Screening only at Weill Cornell and referral to St. Lukes for consenting and studies. Dr. Strain, who was chairperson of the LABS BC work group, will liaison with the Body Composition Laboratory and be involved in patient follow-up, data analysis, and manuscript preparation
4. Randomized, Prospective Trial of PPI vs Placebo in the Prevention of Gastrojejunal Strictures After Laparoscopic Roux-en-Y Gastric Bypass For Morbid Obesity (0511008254)
- PI: Dr. Dakin
- Investigators: Dr. Pomp, Dr. Strain, Ebel and Capasso
Aims:
- Consenting patients (400) will be randomized to receive either Nexium once daily treatment without cost or a placebo (sugar pill) to determine whether the use of proton pump inhibitors (PPIs) will reduce the incidence of narrowing of the gastrojejunal anastomosis (stricture) after laparoscopic gastric bypass surgery
- Patients take the medication for six months and are evaluated at the usual post operative visits for symptoms indicating possible stricture. If clinically indicated, patients will be referred for evaluation and possible dilatation as standard treatment
5. Clinical and Pathophysiologic Consequences of Bariatric Surgery (0704009103)
- PI: Dr. Pomp
- Supported by an NIH subcontract from Columbia
- Investigators: Dr. Dakin, Dr. Strain, Ebel
Aims:
- The purpose of this study is to learn more about body processes that might contribute to the development of obesity. Researchers will analyze body fat cells prior to surgery. If a second procedure is needed to augment the first procedure, fat samples will again be collected at time of surgery to understand the changes in body fat cells after significant weight loss
- If possible, cells from the liver will be examined to study the effects of excessive body fat on the liver and how the liver changes with weight loss
- Small fat samples will be taken during surgery
6. Psychosocial Issues in Bariatric Surgery (0710009452)
- PI: Dr. Strain
- Investigators: Dr. Pomp, Dr. Dakin, Ebel and Capasso
Aims:
- Patients will be asked to participate in telephone interviews conducted by Columbia University concerning psychosocial issues (LABS 3)
- The purpose is to learn more about patients undergoing bariatric surgery and to follow them over time. Specifically, we are trying to find out what types of psychological and eating behavior characteristics will have an impact on the long-term results of bariatric surgery. With this information we may be able to learn what kinds of treatment are most helpful for patients
7. Cognitive Effects of Bariatric Surgery (0711009535)
- PI: Dr. Strain
- Investigators: Dr. Pomp, Dr. Dakin, Ebel and Capasso
- Supported by an NIH subcontract from Columbia
Aims:
- The purpose of this research study is to learn more about the cognitive functioning of patients (75 from Cornell; 150 worldwide) undergoing bariatric surgery and to follow them over time with standardized computerized testing
- Specifically, we are trying to find out if cognitive functioning, or aspects of how the brain works, including memory, concentration, language, intelligence, interpreting information from the senses, and coordinating physical movement, improves in people following bariatric surgery
8. Facilitated Uptake of Long Chain Fatty Acids in Obesity (NIH DK052401)
- PI: Dr. Berk
- PI Cornell: Dr. Pomp
- Investigators: Dr. Dakin, Dr. Strain, Ebel
Aims:
- The purpose of this study is to learn more about body processes that might contribute to the development of obesity. Researchers are looking to determine whether the fat cells in obese subjects (50) are different from fat cells from non-obese subjects
- This study will examine in the laboratory how fat cells take up certain natural compounds called free fatty acids which are then converted to fat in both subject groups
9. Enterra Therapy Gastric Stimulation System (0803009686)
- PI: Dr. Dakin
Aims:
- The Enterra™ system is a device indicated for the treatment of patients with long term, uncontrolled (not helped by medication) nausea and vomiting from gastroparesis of diabetic or idiopathic origin
- This is not an ongoing clinical trial study but requires IRB approval as the FDA gave the Enterra system an approval of a Humanitarian Device Exemption (HDE) of a Humanitarian Use Device (HUD)
10. A Comparison of Caloric Restriction and Gastric Bypass on Glucose Homeostasis (0812010145)
- PI: Dr. Francesco Rubino
- Support: WCMC, Covidien, Medtronic
- Investigators: Drs: Pomp, Dakin, Strain, del Genio, Sinha, Brillon, Polsky, Schulman, Mrs. Ebel and Miss Capasso
Aims:
- This research study is being conducted to increase the understanding of and identify the mechanisms by which blood sugar elevations improve rapidly for some bariatric surgery patients, often before significant weight loss has occurred
- This study will compare glucose homeostasis in subjects with diagnosed Type II diabetes (30) undergoing bariatric surgery either by being kept on a 5 day very low calorie diet (VLCD) before surgery, or after surgery. Subjects will be admitted to our research center
- This study will help to increase our understanding of the differences in glucose homeostasis obtained in subjects undergoing Roux-en-Y Gastric Bypass versus Gastric Banding or Sleeve Gastrectomy
11. Laparoscopic Gastric Bypass for Type 2 Diabetes Mellitus: A Pilot Prospective Study in Overweight and Mildly Obese Subjects (IRB submitted)
- PI: Dr. Rubino
- Support: WCMC and patient self pay
- Investigators: Dr. Pomp, Dr. Dakin, Dr. Strain, Dr. Sinha, Dr. Brillon, Dr. Polsky, Ebel and Capasso
Aims:
- In this pilot study, patients who are either overweight or mildly obese (i.e. with BMIs <35) who request Roux-en-Y Gastric Bypass as an assist to managing their diabetes are given surgery on a self-pay basis and followed for the resolution of their diabetes
- This research study is being conducted to increase the understanding of and identify the mechanisms by which blood sugar elevations improve rapidly for some bariatric surgery patients, often before significant weight loss has occurred
12. Gastric Bypass Surgery Versus Intensive Medical Management in Achieving Glycemic Control in Diabetic Patients with BMI < 35 (IRB submitted)
- PI: Dr. Rubino
- Support: NIH Challenge Grant and Covidien
- Investigators: Dr. Pomp, Dr. Dakin, Dr. Strain, Dr. Sinha, Dr. Brillon, Dr. Polsky, Ebel and Capasso
Aims:
- Patients who are either overweight or mildly obese (i.e. with BMIs <35) who request Rou-en-Y as an assist to managing their diabetes will be able to receive surgery without cost if they agree to random assignment of surgery versus medical management for 2 years prior to surgery
- This research study is being conducted to increase the understanding of and identify the mechanisms by which blood sugar elevations improve rapidly for some bariatric surgery patients, often before significant weight loss has occurred
Our Research Team
Please contact us with any questions you may have about our ongoing research and clinical trials listed above.Gladys Strain, RD, PhD
Director of Research
Department of Surgery, Weight Loss Surgery Program
Email: gls2010@med.cornell.edu
Phone: (212) 746-5661
Fax: (212) 746-8680
Faith Ebel MPH, RD
Research Coordinator
Department of Surgery, Weight Loss Surgery Program
Email: fee2002@med.cornell.edu
Phone: (212) 746-5661
Fax: (212) 746-8680
Michelle Capasso
Research Coordinator
Department of Surgery, Weight Loss Surgery Program
Email: mic2026@med.cornell.edu
Phone: (212) 746-5661
Fax: (212) 746-8680
